I don't see a reason not to do it. I have 4 mail servers sync to each
others and that works very well if you asked me.
The only thing really to be careful about when lots of spamd sync is
use, or when you add lots of entry in it is the default limits in the
table entry of pf.
I also have better results with unicast setup for the sync and you want
to make sure to put a spamd.key as well in the setup.
Works very nicely for me.
Best
Daniel